Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p024 | (1) | SRF2016

Therapeutic doses of phosphoramide mustard cause germ cell death in the prepubertal mouse testis

Rice Siobhan , Smart Ellie , Lopes Federica , Mitchell Rod , Spears Norah

The past few decades have seen marked improvements in life expectancy following childhood cancer due, in part, to advances in chemotherapy. While these drugs are effective in treating malignant disease, one of the main adverse outcomes can be infertility. This is of particular concern for prepubertal boys, for whom there are not yet any established methods of fertility preservation. The objective of this study was to gain a better understanding of the effects of the widely-use...